Non-modulating hypertension. A subset of sodium-sensitive hypertension.

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Non-modulating hypertension. A subset of sodium-sensitive hypertension.

Amajor difficulty in determining the mechanisms responsible for human hypertension is the great variety of systems involved in regulating blood pressure and our tendency to assume that these mechanisms are similar in all hypertensive patients. Even when patients are separated into those whose blood pressure is or is not sensitive to the level of sodium intake, it is often assumed that all "salt...

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A Subset of Sodium-Sensitive Hypertension

Amajor difficulty in determining the mechanisms responsible for human hypertension is the great variety of systems involved in regulating blood pressure and our tendency to assume that these mechanisms are similar in all hypertensive patients. Even when patients are separated into those whose blood pressure is or is not sensitive to the level of sodium intake, it is often assumed that all "salt...

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Non-modulating Hypertension

Patients with normalor high-renin non-modulating essential hypertension fail to shift their adrenal sensitivity on a low sodium diet in response to an infusion of angiotensin II (Ang II). In a prior study, 72 hours of converting enzyme inhibition (CEI) partially corrected this subnormal aldosterone response to Ang II hi patients with non-modulating hypertension. Since it was uncertain whether t...

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Red blood cell lithium-sodium countertransport in non-modulating essential hypertension.

Abnormalities in erythrocyte Li-Na countertransport have been reported in hypertensive subjects, and the available evidence favors familial aggregation and striking heritability of this marker. It is uncertain, however, whether the abnormalities are associated with hypertension per se or whether they may be concentrated in a particular subset of hypertensive subjects. In the present study, maxi...

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Evidence for heritability of non-modulating essential hypertension.

We have previously described a subset of subjects with essential hypertension who fail to appropriately modulate renal vascular and adrenal reactivity with changes in dietary sodium and in response to infused angiotensin II (Ang II). In this paper, we studied these responses in 13 unselected hypertensive subjects in whom the family history of hypertension had been carefully detailed. Nine of th...

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ژورنال

عنوان ژورنال: Hypertension

سال: 1991

ISSN: 0194-911X,1524-4563

DOI: 10.1161/01.hyp.17.1_suppl.i81